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Practical application of nootropics. Effectiveness of use
Nootropics are drugs or nutritional supplements that have a specific effect on higher mental and cognitive functions. The concept of nootropics was first proposed in 1972 with the discovery and description of the properties of piracetam, in particular, its stimulating effect on memory functions. Today there are 18 classes of nootropic compounds, differing in their mechanisms of action – their interaction with receptors of the central nervous system, enzymes and ion channels, growth factors, antioxidant defence system, etc. The clinical efficacy of nootropics is determined by the clinical efficacy of their action.
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Clinical efficacy of nootropics
The mechanism of action of pyrrolidone nootropics is based on the regulation of cholinergic deficiency, enhancement of cholinergic transmission and allosteric regulation of dopamine receptors, due to which their stimulating effect on higher cognitive functions is realised. In addition, compounds of this class contribute to the increase of norepinephrine concentration in brain structures.
Clinical and preclinical studies prove high efficacy of pyrrolidone derivatives in a wide range of neurological and cerebrovascular pathologies accompanied by cognitive disorders.
